Rutin Attenuates Methotrexate-Induced Hepatic Oxidative Stress in Rats

This study aimed to assess the antioxidant effects of rutin on methotrexate-induced hepatic oxidative stress. Wistar Albino rats (n=24) were separated into 4 groups: control group (C); methotrexate (M, 20 mg/kg, single dose) group; (R, 50 mg/kg/day, for fifteen days) and + [MR, (20 (50 days)] group. Rats sacrificed sixteenth day liver tissues removed. The glucose-6-phosphate dehydrogenase (G6PD), glutathione peroxidase (GPx), malondialdehyde (MDA), nicotinamide adenine dinucleotide phosphate (NADPH), total (tGSH), vitamin C determined colorimetrically. Malondialdehyde increased decreased in M compared others (P<0.001). Total reduced both MR groups (P<0.05). An important decrease NADPH GPx (P<0.001) was observed. Nicotinamide R be higher than In this study, it might demonstrate that caused stress had Consequently, can suggested may useful attenuating side liver.